Dopamine-receptor stimulation: biobehavioral and biochemical consequences
Identifieur interne : 003512 ( Main/Exploration ); précédent : 003511; suivant : 003513Dopamine-receptor stimulation: biobehavioral and biochemical consequences
Auteurs : Frédéric Calon [Canada] ; Abdallah Hadj Tahar [Canada] ; Pierre J. Blanchet [Canada] ; Marc Morissette [Canada] ; Richard Grondin [Canada] ; Martin Goulet [Canada] ; Jean-Pierre Doucet [Canada] ; George S. Robertson [Canada] ; Eric Nestler [États-Unis] ; Thérèse Di Paolo [Canada] ; Paul J. Bédard [Canada]Source :
- Trends in Neurosciences [ 0166-2236 ] ; 2000.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Singe.
English descriptors
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Abstract
The MPTP monkey is a well-characterized animal model of parkinsonism and provides an exceptional tool for the study of dyskinesias induced by dopamine-like agents. Several such agents have been tested during the past 15 years, and it has been found that the duration of action of these compounds is the most reliable variable with which to predict their dyskinesiogenic profile. It is proposed that l-dopa-induced dyskinesias represent a form of pathological learning caused by chronic pulsatile (non physiological) stimulation of dopamine receptors, which activates a cascade of molecular and biochemical events. These events include defective regulation of Fos proteins that belong to the ΔFosB family, increased expression of neuropeptides, and defective GABA- and glutamate-mediated neurotransmission in the output structures of the basal ganglia.
Url:
DOI: 10.1016/S1471-1931(00)00026-4
Affiliations:
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Bédard</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Neuroscience Research Unit, Laval University Medical Center (CHUL), Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Dept of Medicine, Faculty of Medicine, Laval University, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Trends in Neurosciences</title><title level="j" type="abbrev">TINS</title><idno type="ISSN">0166-2236</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">23</biblScope><biblScope unit="supplement">S1</biblScope><biblScope unit="page" from="S92">S92</biblScope><biblScope unit="page" to="S100">S100</biblScope></imprint><idno type="ISSN">0166-2236</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0166-2236</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Basal ganglion</term><term>Dopamine receptor</term><term>Dyskinesia</term><term>Gabaergic transmission</term><term>Gene expression</term><term>Glutamatergic transmission</term><term>Levodopa</term><term>Monkey</term><term>Parkinson disease</term><term>Parkinsonism</term><term>Review</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Article synthèse</term><term>Dyskinésie</term><term>Expression génique</term><term>Lévodopa</term><term>Noyau gris central</term><term>Parkinson maladie</term><term>Parkinsonisme</term><term>Récepteur dopaminergique</term><term>Singe</term><term>Transmission gabaergique</term><term>Transmission glutamatergique</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Singe</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The MPTP monkey is a well-characterized animal model of parkinsonism and provides an exceptional tool for the study of dyskinesias induced by dopamine-like agents. Several such agents have been tested during the past 15 years, and it has been found that the duration of action of these compounds is the most reliable variable with which to predict their dyskinesiogenic profile. It is proposed that l-dopa-induced dyskinesias represent a form of pathological learning caused by chronic pulsatile (non physiological) stimulation of dopamine receptors, which activates a cascade of molecular and biochemical events. These events include defective regulation of Fos proteins that belong to the ΔFosB family, increased expression of neuropeptides, and defective GABA- and glutamate-mediated neurotransmission in the output structures of the basal ganglia.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Connecticut</li></region></list><tree><country name="Canada"><noRegion><name sortKey="Calon, Frederic" sort="Calon, Frederic" uniqKey="Calon F" first="Frédéric" last="Calon">Frédéric Calon</name></noRegion><name sortKey="Bedard, Paul J" sort="Bedard, Paul J" uniqKey="Bedard P" first="Paul J." last="Bédard">Paul J. Bédard</name><name sortKey="Bedard, Paul J" sort="Bedard, Paul J" uniqKey="Bedard P" first="Paul J." last="Bédard">Paul J. Bédard</name><name sortKey="Blanchet, Pierre J" sort="Blanchet, Pierre J" uniqKey="Blanchet P" first="Pierre J." last="Blanchet">Pierre J. Blanchet</name><name sortKey="Blanchet, Pierre J" sort="Blanchet, Pierre J" uniqKey="Blanchet P" first="Pierre J." last="Blanchet">Pierre J. Blanchet</name><name sortKey="Calon, Frederic" sort="Calon, Frederic" uniqKey="Calon F" first="Frédéric" last="Calon">Frédéric Calon</name><name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Thérèse" last="Di Paolo">Thérèse Di Paolo</name><name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Thérèse" last="Di Paolo">Thérèse Di Paolo</name><name sortKey="Doucet, Jean Pierre" sort="Doucet, Jean Pierre" uniqKey="Doucet J" first="Jean-Pierre" last="Doucet">Jean-Pierre Doucet</name><name sortKey="Goulet, Martin" sort="Goulet, Martin" uniqKey="Goulet M" first="Martin" last="Goulet">Martin Goulet</name><name sortKey="Goulet, Martin" sort="Goulet, Martin" uniqKey="Goulet M" first="Martin" last="Goulet">Martin Goulet</name><name sortKey="Grondin, Richard" sort="Grondin, Richard" uniqKey="Grondin R" first="Richard" last="Grondin">Richard Grondin</name><name sortKey="Grondin, Richard" sort="Grondin, Richard" uniqKey="Grondin R" first="Richard" last="Grondin">Richard Grondin</name><name sortKey="Grondin, Richard" sort="Grondin, Richard" uniqKey="Grondin R" first="Richard" last="Grondin">Richard Grondin</name><name sortKey="Grondin, Richard" sort="Grondin, Richard" uniqKey="Grondin R" first="Richard" last="Grondin">Richard Grondin</name><name sortKey="Morissette, Marc" sort="Morissette, Marc" uniqKey="Morissette M" first="Marc" last="Morissette">Marc Morissette</name><name sortKey="Morissette, Marc" sort="Morissette, Marc" uniqKey="Morissette M" first="Marc" last="Morissette">Marc Morissette</name><name sortKey="Robertson, George S" sort="Robertson, George S" uniqKey="Robertson G" first="George S." last="Robertson">George S. Robertson</name><name sortKey="Tahar, Abdallah Hadj" sort="Tahar, Abdallah Hadj" uniqKey="Tahar A" first="Abdallah Hadj" last="Tahar">Abdallah Hadj Tahar</name><name sortKey="Tahar, Abdallah Hadj" sort="Tahar, Abdallah Hadj" uniqKey="Tahar A" first="Abdallah Hadj" last="Tahar">Abdallah Hadj Tahar</name></country><country name="États-Unis"><region name="Connecticut"><name sortKey="Nestler, Eric" sort="Nestler, Eric" uniqKey="Nestler E" first="Eric" last="Nestler">Eric Nestler</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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